Vitamin C deficiency

Pascorbin

Pascorbin 7,5g Ascorbinsäure / 50 ml Packshot PZN 00581310[Translate to Englisch:] Ihre Vorteile[Translate to Englisch:] Gute Gründe für Pascorbin[Translate to Englisch:] Vitamin-C-Mangel[Translate to Englisch:] Schnelle Verfügbarkeit von Vitamin C[Translate to Englisch:] Pascorbin
50 ml

Treatment of clinical vitamin C deficiency states that cannot be corrected through nutrition or oral substitution.

The benefits of Pascorbin® at a glance:

  • The number 1 high-dose vitamin C infusion in Germany and other European countries* *IH-Galaxy 12/2019 
  • Pascorbin® enters the bloodstream directly and immediately supplies you with vitamin C
  • So significantly faster availability than with tablets
  • The first and only authorised brand product with 7.5 g vitamin C - available in this tried and tested dosage since 1978
  • Over 40 years of expertise in high-dose vitamin C infusion
  • No stabilisers and preservatives 
  • Lactose-, gluten- and sugar-free
  • Approved for use from 12 years
  • Pascorbin® 7.5 g has been one of our company’s products for over 40 years.

    A severe vitamin C deficiency can occur due to:
     
  • Acute and chronic infections
  • Chronic inflammatory diseases, e.g. arthritis
  • Absorption disorders in the intestines
  • After surgery

Making vitamin C available faster

For a vitamin C deficiency that cannot be remedied through diet, infusions are one way of correcting this deficiency. Vitamin C is absorbed in the small intestine via special transporter molecules and then passed on into the bloodstream. The number of these transporters is limited, which is why only part of the total quantity of vitamin C consumed reaches the bloodstream. Our bodies can absorb much higher levels of vitamin C from an infusion. Such high blood levels cannot be attained through diet and tablets.

Infusion therapy: therapists in your area

Find your local practice. Use our Therapist Search function at: www.naturheilkunde.de. The website also provides interesting information about all aspects of naturopathy.

The vitamin of life – 3 facts about vitamin C

  • Vitam in C is water soluble which means it cannot be stored.
  • Most animals can use their own metabolism to synthesize large quantities of vitamin C.
  • Humans lost this ability sometime during the course of evolution.

Because your body cannot produce vitamin C itself, it has to be supplied from external sources.

In the interview with Dr Claudia Vollbracht, Graduate Human Biologist, M.Sc. Naturopathy and Complementary Medicine, Medical Science Specialist and Vitamin C Expert, you will learn about the importance of a balanced diet and the advantages of an infusion compared with taking tablets. 

Click here to go directly to the podcast:

Vitamin C podcast

What’s worth knowing on the subject of vitamin-C deficiency can be found in our vitamin C film:

Vitamin C film

[*] Marketing authorisation issued by the German Federal Institute for Drugs and Medical Devices (BfArM)

Frequently asked questions on all aspects of high-dose vitamin C infusion

1. High-dose vitamin C: What is it?
2. Why infuse vitamin C rather than simply swallowing it?
3. Vitamin C infusion: How is the infusion given?
4. How much does a vitamin C infusion cost?
5. How long does a vitamin C infusion work for?
6. Does vitamin C have side effects?
7. Can too much vitamin C be harmful?
8. Where can I get a vitamin C infusion? – Practices in your area?
9. As a specialist, where can I get scientific information?

1. High-dose vitamin C: What is it?

In many people’s view, tablets which contain 500 to 1,000 mg vitamin C already contain too high a dosage. This is because the DGE (German Nutrition Society) estimates in their recommendations that about 100 mg per day is sufficient. Even for smokers who have a higher requirement, the DGE recommends only 155 mg daily. Nutritional scientists and physicians do not always consider these quantities sufficient. This is because the recommendations refer to completely healthy people only. Vitamin C requirement increases during many illnesses. People with vitamin C deficiency are sadly not a rare phenomenon. Either their vitamin C intake is insufficient or the body cannot absorb enough from the diet or they consume too much, because of illness for example.
If deficiency is present and the amounts required cannot be supplied to a sufficient extent via the diet or via tablets, vitamin C infusions are a means of remedying this deficiency. In this way, amounts of vitamin C in the gram range can be directly supplied to the blood. 
With the aid of a Pascorbin infusion these can be 7,500 mg for example, 7.5 g per infusion therefore. A high-dose infusion contains about 75 times the amount of vitamin C generally recommended for daily consumption. 

2. Why infuse vitamin C rather than simply swallowing it?

The advantage of an infusion: All of the vitamin C administered as an infusion is directly available to the body. Nothing is lost because of restricted absorption in the intestine. This is called 100 % bioavailability.
When vitamin C is swallowed, bioavailability is much lower. Even in completely healthy people, only part of the vitamin C, which may well have been supplied in sufficient quantities in the diet or in nutritional supplements, actually reaches the blood.
Chronic inflammation and absorption disorders in the gastrointestinal tract can further reduce this amount. Only the vitamin C that actually reaches the blood and thus can be distributed throughout the whole body, is available to the cells of the body.

3. Vitamin C infusion: How is the infusion given?

If you have an appointment for a high-dose vitamin C infusion with Pascorbin 7.5 g, you will receive the vitamin C infused directly into your veins through an infusion system. The procedure can vary somewhat at the discretion of your doctor or alternative practitioner. 
First Pascorbin is diluted with an appropriate carrier solution (generally 0.9% saline solution) and then infused via what is known as a venipuncture cannula (e.g. butterfly) or indwelling venous cannula (e.g. braunule) directly into your veins. It generally takes approx. 20 to 30 minutes until an infusion of this kind has been fully transported into your veins. 
It is clarified in advance whether there are any concerns about your inability to tolerate the infusion. Certain blood results and information about possible previous diseases may provide information about this. Read more on this under the question: Can too much vitamin C be harmful?

4. How much does a vitamin C infusion cost? 

There is no easy answer to this question. It depends on the purchase price of Pascorbin and the other infusion equipment, which can vary greatly depending on the pharmacist.
Practices also charge different amounts for the services they offer: In some contexts there are flat rate prices for infusion therapy and in others every individual item is invoiced. So it’s best to discuss the costs in advance directly with your practice.

5. How long does a vitamin C infusion work for?

You may already have been confronted with the statement that there is no point infusing vitamin C in the gram range, because vitamin C cannot be stored and hence everything unused is excreted via the kidneys?
This statement is true in part. Vitamin C is difficult to store – so any “excess” is excreted relatively quickly via the urine. This limitation of therapy is actually a great advantage however: it is completely certain that overdose is almost impossible.
The high vitamin C levels in the blood which occur directly after an infusion remain for a few hours only. How many hours this is, depends on the actual individual requirement and excretion via the kidneys. 
A vitamin C deficiency in the blood reflects undersupply to the tissue. The high blood levels after an infusion have the advantage that deficiencies in the tissue and organs can be rapidly corrected. Regions with acute inflammation which is accompanied by high vitamin C requirement are some of the regions that benefit from this. 
In people with a very severe deficiency, which repeatedly occurs anew because their condition is associated with a very high vitamin C requirement, multiple infusions may also be necessary.

6. Does vitamin C have side effects?

Some people think that they do not tolerate vitamin C because they experience hypersensitivity reactions – to citrus fruits for example. Citrus fruit allergies are not allergies to vitamin C but to other ingredients. As vitamin C is a vital substance, we would not be alive if we had a vitamin C allergy. To date, “vitamin C intolerance” is unknown to science.
Vitamin C in the form of an infusion is generally very well tolerated – assuming no preservatives or similar are actually included. Pascorbin is free of additives of this kind. 
Mild irritation at the injection site may occur during the infusion. Other hypersensitivity reactions (skin, respiration, circulation) are very rare but cannot be excluded in individual cases. Very rarely, high dosages of ascorbic acid can cause problems in the digestive tract (e.g. nausea, vomiting, diarrhoea). This occurs much more frequently at high oral intake.
The observation that cold symptoms can initially worsen temporarily after a vitamin C infusion is interesting. This can be interpreted as a sign of immune system support.

7. Can too much vitamin C be harmful?

As already mentioned under 5. above, vitamin C is difficult to store. This also has one great advantage however:
The risk of an “overdose” is very low. Any "excess" is rapidly excreted via the kidneys.
Despite this, there are situations and underlying diseases in which you should not use high-dose vitamin C infusions. This primarily applies when iron levels in the blood are too high as they are in so-called iron storage diseases. Vitamin C infusions should not be given to people who have a tendency to develop kidney stones (oxalate stones).
Even if the kidneys do not function properly (kidney failure), too much vitamin C should not be taken. 
Some people have a genetic deficiency of a certain enzyme (G6PDH). They should not take more than 500 mg daily.
As vitamin C both passes into the breast milk and crosses the placenta, pregnant and breast-feeding women should not be given more than 500 mg daily.
Last but not least, interactions with some medicines cannot be excluded: Always discuss with your doctor or alternative practitioner therefore whether vitamin C infusions are really appropriate for you.
Otherwise the following applies: Drink plenty of fluids in the hour after a high-dose vitamin C infusion!
Important note: High vitamin C levels in the blood may impair detection of certain measured blood values. This applies in particular to glucose detection in people with diabetes. 
Therefore: Do not rely on the values measured in your blood that are taken several hours after a high-dose vitamin C infusion.

8. Where can I get a vitamin C infusion? – Practices in your area

Many naturopathic practices now offer vitamin C infusions. Maybe you know someone who has similar experiences and can give you some advice.
Otherwise you can use our Therapist Search function. You can find this at: www.naturheilkunde.de. There you can search for doctors and alternative practitioners in your post code area. If you also search for “infusion therapy” under “therapies” you will find a selection of practices which offer the therapy in question. You generally obtain a link to the relevant practice website so you can get an idea of what they offer.
The website www.naturheilkunde.de also provides interesting information about all aspects of naturopathy and extensive information about vitamin C infusion therapy.

9. As a specialist, where can I get scientific information?

As a specialist you can use a Pascoe login or DocCheck password to register on the pages for specialists of www.pascoe.de (top right).
There you can find further information on medical and scientific questions on all aspects of vitamin C. 
Some good advice. Register there for the specialist newsletter too. Once a month you will be sent, in 3-6 articles, the most important findings on vitamin C and other naturopathy and Pascoe themes presented briefly and concisely.

Dosage

5 ml ampoule:

Administer 5 ml daily by slow intravenous injection and up to 50 ml solution for injection when added to an infusion.

50 ml vial:

For peripheral venous short infusion, 50 ml Pascorbin should be diluted with 100 ml isotonic saline solution and infused slowly.

Vitamin C replacement therapy during parenteral nutrition:

For prophylaxis of vitamin C deficiency during prolonged parenteral nutrition

  • Adults: administer 100 to 500 mg ascorbic acid per day intravenously. 
  • (corresponds to 0.7 ml to 3.3 ml Pascorbin®).
  • Children: administer 5 to 7 mg ascorbic acid/kg body weight per day intravenously.

Methaemoglobinaemia in childhood:

A single dose of 500 to 1000 mg ascorbic acid (equivalent to 3.3 ml to 6.6 ml Pascorbin®) should be administered by intravenous injection. If necessary, the same dose can be repeated. Do not exceed a dose of 100 mg/kg body weight per day.

Do not self-medicate with injections. Injection therapy should be administered by a doctor or an alternative practitioner.

How is a high-dose vitamin C infusion with Pascorbin 7.5 g administered?

The ascorbic acid in Pascorbin® 7.5 g is highly concentrated. Therefore, the Pascorbin® 7.5 g must be diluted with a suitable carrier solution.
A suitable carrier solution is, for example, 0.9% saline solution. You need at least 100 ml of this saline solution if you want to infuse 50 ml Pascorbin® 7.5 g. The prepared infusion solution is then administered using an infusion set and a butterfly cannula (or braunule = peripheral venous catheter). 
This type of infusion takes about 20–30 min.

No age limit (dosage restriction for children)


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Vitamin C
Vitamin C (Ascorbinsäure)

1 ml of solution for injection contains 150 mg ascorbic acid.
Each 5 ml ampoule contains:

Active substance

ascorbic acid 750 mg
Excipients: sodium bicarbonate, water for injection.
1 vial with 50 ml solution for injection contains:

Active substance

ascorbic acid 7.5 g
Excipients: sodium bicarbonate, water for injection.

Pascorbin®
Active substance: ascorbic acid 150 mg per ml solution for injection. Areas of application: for the treatment of clinical vitamin C deficiencies, which cannot be remedied through nutrition or substituted by an oral route. Methaemoglobinaemia in infancy. Contains sodium bicarbonate. Please read the package insert for information on possible risks and side effects, and consult your doctor or pharmacist. Pascoe pharmazeutische Präparate GmbH, D-35383 Giessen, info@pascoe.de, www.pascoe.de